Portland Fire and Rescue says just after 3:30 a.m. Sunday Morning, crews responded to reports of an apartment fire at 2226 NE Weidler.
When crews arrived they found two apartment buildings fully involved.
The fire was rapidly upgraded resulting in 4 alarms.
According to Portland Fire and Rescue, two people were taken to local hospitals with unknown injuries at this time, and multiple people were treated on scene.
Investigators are on scene working on a cause determination.